Infants exposed to specific molds have higher asthma risk

ScienceDaily (Aug. 2, 2012) ? In the United States, one in 10 children suffers from asthma but the potential environmental factors contributing to the disease are not well known. Cincinnati-based researchers now report new evidence that exposure to three types of mold during infancy may have a direct link to asthma development during childhood.

These forms of mold -- Aspergillus ochraceus, Aspergillus unguis and Penicillium variabile -- are typically found growing in water-damaged homes, putting a spotlight on the importance of mold remediation for public health.

Lead author Tiina Reponen, PhD, and colleagues report these findings in the August 2012 issue of the Journal of Allergy and Clinical Immunology, the official scientific publication of the American Academy of Allergy, Asthma and Immunology.

In a long-term population study of nearly 300 infants,, researchers from the University of Cincinnati (UC), U.S. Environmental Protection Agency (EPA) and Cincinnati Children's Hospital Medical Center assessed allergy development and the respiratory health of children annually for the first four years of life then again at age 7 -- an early age for objective diagnosis of asthma in children. The team also monitored home allergens and mold. All infants enrolled in the study were born to at least one parent with allergies.

They found that 25 percent of children whose parents had allergies were asthmatic by age 7. Among the multiple indoor contaminants assessed, only mold exposure during infancy emerged as a risk factor for asthma at age 7.

"Previous scientific studies have linked mold to worsening asthma symptoms, but the relevant mold species and their concentrations were unknown, making it difficult for public health officials to develop tools to effectively address the underlying source of the problem," explains Reponen, who is a professor in the UC College of Medicine's environmental health department.

The UC-based team used the environmental relative moldiness index (ERMI), a DNA-based mold level analysis tool, to determine that exposure to Aspergillus ochraceus, Aspergillus unguis and Penicillium variabile was linked to asthma development in the high-risk study population. The ERMI tool was developed by the EPA to combine analysis results of 36 different types of mold into one index that describes a home's cumulative mold burden.

"This is strong evidence that indoor mold contributed to asthma development and this stresses the urgent need for remediating water damage in homes, particularly in lower income, urban areas where this is a common issue," says Reponen. "Therapeutics for asthma may be more efficient if targeted toward specific mold species."

Children included in this study were part of the Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS), a long-term population-based study of more than 700 children from the Greater Cincinnati area. CCAAPS looked at the effects of environmental particles on childhood respiratory health and allergy development. Participants were identified during infancy as at high risk to develop allergies based on family medical history

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The above story is reprinted from materials provided by University of Cincinnati Academic Health Center.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Tiina Reponen, James Lockey, David I. Bernstein, Stephen J. Vesper, Linda Levin, Gurjit K. Khurana Hershey, Shu Zheng, Patrick Ryan, Sergey A. Grinshpun, Manuel Villareal, Grace LeMasters. Infant origins of childhood asthma associated with specific molds. Journal of Allergy and Clinical Immunology, 2012; DOI: 10.1016/j.jaci.2012.05.030

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/3iyDU144HbQ/120802111502.htm

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Cameron, Putin to trade blows, watch Olympic judo

LONDON (AP) ? Prime Minister David Cameron will hold discussions Thursday in London with Russian President Vladimir Putin, but appears likely to focus on boosting trade, rather than anger over Moscow's sheltering of Syrian President Bashar Assad's regime from tougher international action.

With relations thawing since the end of a five-year freeze on top-level contacts between Britain and Russia, Cameron also is planning to take Putin to London's Olympic Park to see matches in the Russian leader's beloved judo competition.

The visit by Putin, an honorary president of the International Judo Federation, will be his first to Britain since he was reinstalled as Russia's chief in May and follows talks with Cameron on the sidelines of May's G-20 meeting in Mexico.

Cameron will push Putin over Russia's refusal to back a new resolution at the United Nations aimed at helping to halt Syria's violence. Britain called the decision by Russia and China to veto a resolution two weeks ago "inexcusable and indefensible."

But, as with much of Britain's frantic round of Olympic diplomacy ? aimed at winning 1 billion pounds (US$1.6 billion) in new trade on the back of the Summer Games, talks will stress efforts to increase the country's exports to Russia.

"We will be at the judo, so it may be a bit off-putting, but nonetheless, I know my major priority is to get those trade deals to get that investment and not to concentrate on what's happening on the mat," Cameron said last week, addressing an audience of business leaders.

Relations between Britain and Russia soured over the 2006 poisoning death of dissident ex-Russian security agent Alexander Litvinenko in London. Litvinenko made a deathbed statement accusing Putin of authorizing his killing.

Russia has refused repeated British requests for the extradition of the chief suspect in the case, ex-KGB agent Andrei Lugovoi, who denies any involvement.

Intelligence cooperation between Britain and Russia remains suspended as a result of Litvinenko's killing.

Leaders of the two countries didn't meet for five years as a result, but in a visit to Moscow last September Cameron acknowledged that the two nations must set aside their disputes to nurture new trading ties.

"This issue hasn't been parked, the fact is that the two governments don't agree," Cameron told reporters.

During that visit, Putin ? then Russia's prime minister ? cast doubt on Britain's aims of strengthening trade links. He said Britain's investments "in the real sector of the economy are rather modest."

Cameron's office said it was not yet known which judo matches the leaders would watch on Thursday.

Tagir Khaibulaev, 28, from Dagestan, and Britain's James Austin, 29, from Burton-upon-Trent, in central England, are both competing Thursday in the men's sub-100kg judo category. Russian Vera Moskalyuk, 30, and Londoner Gemma Gibbons, 25, will fight in the women's sub-78kg category.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2012-08-02-OLY-Britain-Russia/id-9811caaf662b4783bdf1e27b29549ef6

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Could online poker in the U.S. still have an ace up its sleeve ...

Two overseas online poker firms have settled money laundering charges for $731 million. Does online poker have a future in the U.S.?

The U.S. government has taken a dim view towards online gambling since the passage of the Unlawful Internet Gambling Enforcement Act in 2006. Now, two online poker companies operating outside the United States ? PokerStars and Full Tilt Poker ? have reached a settlement with the Justice Department totaling some $731 million ? and customers will be reimbursed for money they had on deposit. Although the companies don?t admit to any wrongdoing, the settlement resolves charges they effectively engaged in money laundering to accept illegal bets, and potentially clears the way for PokerStars (which is surviving the deal) to resume operations in the United States ? if ? or more likely, when ? Internet gambling becomes legal.

Boom?

Prior to 2006, Internet-based gambling was effectively legal in the United States. Although the Federal Wire Act from 1961 prohibited transmission of sports betting information using telecommunications services, in 2002 a U.S. appeals court ruled that the sports-related provisions in the Wire Act did not preclude Internet gambling. Although some states and jurisdictions did have laws on the books specifically prohibiting online gambling, many did not ? and so started a bit of an online gold rush as online gambling companies tried to capture chunks of the lucrative U.S. market.

As it turned out, most established U.S. casino operators and gaming companies chose not to get into the online gambling market, fearing the legal exposure from differing legal standards in different markets and an uncertain political environment ? gambling, after all, is still a hot-button issue. Aside from issues of age verification, credit card fraud, and myriad of other obstacles presented by online gambling, how were online gambling operators to know that a player was located in a jurisdiction where online gambling was legal? Established U.S. gaming companies didn?t want to take the chance ? and potentially put pressure on their existing businesses? relationships with tax and regulatory authorities.

So overseas companies lept at the opportunity, and soon three firms came to dominate the U.S. online poker market: PokerStars, Full Tilt Poker, and Absolute Poker. PokerStars and Full Tilt are incorporated in the Isle of Man and the Channel Islands, respectively; Absolute Poker operates out of Antigua. All three companies were happy to accept payments from U.S. players, and the firms also engaged in high-profile advertising and promoted poker competitions to increase their visibility. The companies quickly became household names in the poker world, and the strategy worked: according to research firm H2 Gambling Capital, the U.S. online poker market comprised about 1.9 million players and over $18 billion in bets in 2010.

?and bust

But that?s jumping ahead a bit. In 2006, the U.S. enacted the Unlawful Internet Gambling Enforcement Act (UIGEA), following what has often been described as a dubious legislative process. The act contains a provision in a title related to port security (yes, really) that bars ?gambling businesses from knowingly accepting payments in connection with the participation of another person in a bet or wager that involves the use of the Internet and that is unlawful under any federal or state law.? The law had some immediate impacts, and is generally consider the end of the ?boom? in online poker: most overseas public companies that were accepting online bets from U.S. gamblers (like the UK?s PartyGaming) stopped doing so, but most privately-held firms continued to accept U.S. customers. Critics voices concerns that the shifting of online gamling operations to private companies increased the likelihood of unscrupulous firms operating in the market ? perhaps companies that would turn a blind eye to underage gamblers and money laundering.

The UIGEA was at the center of a bitter World Trade Organization dispute between the U.S. and Antigua over the U.S.?s limitations on online gambling. Antique argued the U.S. was unfairly blocking its market to Antiguan gambling companies ? and Antigua won. The U.S. settled the dispute not by lifting restrictions on online gambling operations, but by granting undisclosed other concessions. The terms of that settlement have not been made public.

Despite UIGEA being on the books, PokerStars, Full Tilt, Absolute Poker remained the largest Internet poker companies, and they continued to accept U.S players under the belief that the law could not be applied to poker ? it?s a game of skill, not a game of chance, right? Then on April 15, 2011, the U.S. Department of Justice charged the owners of PokerStars, Full Tilt, and Cereus (the parent company of Absolute Poker) of engaging in bank fraud and money laundering to process money transfers from U.S. gamblers ? it?s still called ?Black Friday? in the online poker world. The U.S. seized the .com domains operated by the three companies ? along with 76 bank accounts spanning 145 countries ? and issued criminal charges against eleven individuals, including site founders and executives. At the heart of the case: a small Utah bank (SunFirst) that miscoded transactions from the companies in an apparent effort to evade UIGEA. Instead of posting transactions for Internet gambling sites ? which most U.S. banks and credit card companies would refuse to process ? the bank would post online purchases for things like jewelry, golf balls, and dog food.

How the settlement works

Now, two of the three major online poker companies ? PokerStars and Full Tilt ? have come to settlement terms with the Justice Department. PokerStars will pay $547 million to the DOJ, and another $184 million to poker players owed money by Full Tilt Poker. As part of the deal, PokerStars will acquire all the assets of Full Tilt, and Full Tilt?s U.S. fraud ?victims? will be able to seek compensation from the $547 million PokerStars is giving to the Justice Department. Reports have about $150 million credited to U.S. players? Full Tilt accounts. PokerStars plans to keep the Full Tilt brand around, albeit outside the United States.

Neither company admits to any wrongdoing, and both maintain that online poker is legal, despite U.S. restrictions on Internet gambling. The settlement dismisses the civil complaints against both companies with prejudice ? meaning the Justice Department can?t turn around and resurrect them to have another go at the companies if it likes. However the criminal charges against the eleven individuals named in the case ? including the CEOs and Directors of Payments for both companies, as with payment processors and a vice chairman of SunFirst Bank ? remain in place.

Interestingly, the deal would also permit PokerStars to operate in the United States if a legal framework emerges that legitimizes online poker.

Absolute Poker has also reached an agreement to turn over assets to the Justice Department; however, the settlement has not yet been approved.

Does online poker have a future in the U.S.?

Is there a chance U.S. online gambling regulations might change? In a word, yes.

At the same time the Justice Department was suing PokerStars, Full Tilt, and Absolute Poker, it did something else curious: out of the blue, it issued an opinion that the 1961 Wire Act ? kind of the heart of all online gambling regulation in the United States ? does not prohibit states from authorizing online gambling within their own borders. The opinion (pdf) was ostensibly offered only to answer a question about whether New York and Illinois could legally use out-of-state transaction processors to sell in-state lottery tickets, but it has broad implications. Individual states could decide that online gambling is perfectly acceptable within their borders.

Unsurprisingly, states are jumping at the opportunity. Nevada was the first through the gate, issuing its first online gambling licenses to Bally?s and IGT back in June. Immediately on Nevada?s heels, Delaware approved legislation allowing full-service online betting sites.

For states, online gambling represents a potentially lucrative new revenue stream: where operations like PokerStars and Absolute Poker largely operate outside U.S. tax and regulatory frameworks, individual states can issue licenses and set terms for online gambling operations ? and get a cut of the revenue to bolster state coffers. Nevada is charging companies half a million dollars for an online gaming license, and $250,000 a year for renewals. To gaming companies, that?s pocket change ? and the amount is intended to make Nevada a premiere destination for online gaming operators. California, in contrast, is considering legislation that would demand $1 to $5 million just to apply for a license ? if granted, companies would have to pony up another $30 million as a credit against monthly taxes on gaming revenue.

Nonetheless, the legal framework for offering online gambling in the United States is far from clear ? and a state-by-state approach may ultimately dissuade many companies from getting involved. The sheer overhead of potentially managing dozens of separate online gambling licenses and regulatory frameworks would not be insignificant. However, states are increasingly looking to gambling and things like lotteries as ways to bolster state revenue, and have noted the fiscal success of tribal casinos and limited casino operations. It?s probably only a matter of time before a significant minority of states legitimize online gambling ? it?s just more likely the operations will be run by the same folks running local casinos, not corporations incorporated in overseas tax havens.

[Cards & chips mage via whitewizzard/Shutterstock?Cash image via suravid/Shutterstock]

Source: http://www.digitaltrends.com/gaming/could-online-poker-in-the-us-still-have-an-ace-up-its-sleeve/

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Mathematicians solve decade-old debate on regulation of protein production by microRNAs in cells

ScienceDaily (July 31, 2012) ? An international team of mathematicians has proposed a new solution to understanding a biological puzzle that has confounded molecular biologists.

They have applied a mathematical model to work out the functioning of small molecules known as microRNAs -- components of the body akin to the electronics in modern airplanes.

For a long time molecular biologists thought that the major role of RNA in living cells was to serve as a copy of a gene and a template for producing proteins, major cell building blocks. This belief had been changed at the end of 90s when it was found that myriads of RNA molecules are involved in regulating speeds of practically all molecular mechanisms in a cell. These abundant molecules are essential in regulating the speed of protein production- a vital function in bodily processes, including development, differentiation and cancer.

The problem to date has been that scientists have differed over interpretations of how the production of the major building blocks of a cell, proteins, is controlled by microRNAs.

Basically, there were different and sometimes conflicting theories about ways in which microRNAs regulate protein production since the results varied depending on only slightly changed experimental conditions.

Professor Alexander Gorban, who holds a Chair in Applied Mathematics at University of Leicester, said: "The old metaphor of an elephant and blind scientists trying to describe it will be always relevant to science. However, often we use it only as a metaphor, as a generic statement. In this project the elephant's metaphor can be applied literally as a working principle.

"Different biological labs or slightly changed experimental conditions meant that results were different for investigators.

"Quite dramatically, there has been a series of reports in top-ranked journals with contradictory results supporting one or another mechanism. Furthermore, researchers are puzzled by the fact that the same couple of protein and microRNA demonstrate different mechanisms of regulation in different biological labs or in slightly changed experimental conditions."

The mathematical model constructed by Professor Gorban from University of Leicester and Andrei Zinovyev from Institut Curie in Paris in collaboration with biologists Nadya Morozova and Annick Harel-Bellan from CNRS in France showed that there might be one simple mechanism which manifests itself differently in different conditions. Their findings are due to be published in the RNA Journal.

Professor Gorban said: "We have shown that what appeared to be very different mechanisms are in fact manifestations of one relatively simple biochemical reaction, but taking place in various contexts.

"Our model proposes that microRNA performs many actions simultaneously to the protein development, basically acting to get the job done (regulating the speed of protein production) in a stable and efficient way, given whatever conditions the experiment is occurring in.

"If this model is accepted, we would be able to take active steps in determining what the main mechanism of microRNA action is, as the model suggests experiments to verify the hypothesis. This in turn should lead to a resolution of a decade long debate to understand the means in which these very important molecules actually work."

Pat Heslop-Harrison, Professor of Cell Biology at the University of Leicester, said: "The discovery of miRNA and its regulatory role has completely changed our view of how genes in cells are controlled.

"Understanding all the ways the regulation is happening and interpreting experimental evidence has proved a huge challenge. In this important new paper, Alexander, Andrei, Nadya and colleagues overview the characteristic features of no less than nine different mechanisms, and then generate a unifying model of the whole system integrating the nine mechanisms.

"The multifunctional model gives dynamic predictions of gene control; it can now be tested to understand significance of the various mechanisms coexisiting under different conditions. It will be exciting to link this back the huge range of functions and responses of organisms and understanding miRNA control mechanisms is a systematic and predictive way."

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Story Source:

The above story is reprinted from materials provided by University of Leicester, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Nadya Morozova, Andrei Zinovyev, Nora Nonne, Linda-Louise Pritchard, Alexander N. Gorban, and Annick Harel-Bellan. Kinetic signatures of microRNA modes of action. RNA, July 31, 2012 DOI: 10.1261/rna.032284.112

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2012/07/120731134956.htm

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Principles of Business STOCKS homework question? ? goldsenze ...

Susan Haugen bought $ 5,000 of gold mining stocks a few years ago. Last Week, she received a letter saying that the company went out of business. It could not operate profitably, so it closed down. How much of her investment might Susan lose?

it depends on the loss that the company is facing.

thank you.

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